Market SegmentsAnalytical & ResearchSFC

SFC: A Greener Approach to Analytical and Purification Applications

For laboratories overwhelmed with solvent disposal and time-consuming solvent cleanup, supercritical fluid chromatography (SFC) is a beneficial alternative to purification and analytical applications. Considered a leading "green" purification technology, SFC systems from Waters are used to separate and isolate chiral and achiral chemical compounds using various methods of detection.

The principles of SFC are similar to those of liquid chromatography, however SFC typically uses carbon dioxide as the main mobile phase. SFC is essentially a normal-phase chromatographic technique with inherent high speed and efficiency due to its mobile phase. As a high pressure liquid, or supercritical fluid, using CO2 is a smart solvent for its low viscosity and high diffusivity needed in today's demanding purification labs and also a sustainable solvent as it is reused after being discarded from other industrial processes.

SFC excels at separating and purifying chiral compounds and natural products because it's faster, uses much less solvent, and overall is a less expensive and greener method that exceeds high pressure liquid chromatography (HPLC) in performance for chiral separations.

Whether you're just looking to analyze chiral compounds or need to purify those compounds, Waters has the solution that fits your needs.

The first UPLC-based SFC system that provides unprecedented advantages compared to normal phase HPLC. This approach for chiral and achiral separations minimizes harmful waste while gaining superior sensitivity, resolution, and speed.

Method Station SFC System
The analytical Method Station SFC System is a methods development system for screening multiple compounds with multiple columns and multiple mobile phase compositions.

Method Station X5 SFC System
The analytical Method Station X5 SFC System is a step forward in chiral column screening.

Resolution SFC MS System
A seamlessly integrated analytical SFC MS system that combines the Method Station SFC System with the 3100 single quadrupole mass detector.

Investigator SFC System
For when you need to purify a large amount of single samples, but still do method development. The analytical/semi-prep Investigator SFC has the unique ability to isolate and collect less than 1 gram of a specific compound.

Prep 100 SFC MS Directed System
The first commercialized supercritical fluid chromatography (SFC) system specifically designed for seamless, mass-triggered purification. Features open-bed automated sample handling and collection with the power of Waters mass detection.

SFC 80/200/350 Preparative Systems
Waters SFC 80, 200, and 350 Preparative systems for bulk-scale purification offer the optimal system for the amount of sample you need to purify. These systems easily allow you to purify a large amount of one sample.

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